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Studies have reported that Cu ions contribute to aberrant lipoylated protein aggregation, leading to the downregulated Fe-S cluster protein level, which induces proteotoxic stress, finally causing cell death

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Initial studies reported that concentrations of AFB 1 which are likely to be achieved in the liver following ingestion of real-world concentrations of AFB 1 are bioactivated to AFBO primarily by CYP1A2, whereas much higher concentrations are catalyzed by CYP3A4 [30], [46], [79]

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The effectiveness of oncolytic viruses against tumors has been demonstrated in numerous clinical trials, with T-VEC, a first-generation recombinant herpes simplex virus, emerging as the most notable example to date (Russell and Barber, 2018)

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