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Gegebenenfalls werden zur genaueren Abklrung weitere Laborwerte erhoben

Since the discovery of the genetic etiology of AS, extensive efforts have been devoted to the understanding of the underlying mechanisms of AS pathophysiology, mainly by utilizing the AS mouse model, which was shown to replicate multiple phenotypes of the human disorder [5, 6]

doi:10.1002/mus.26764

As mentioned above, the first is stimulation of the AT1 receptor by angiotensin II which further activates phospholipase C and its activation leads to an increase in cytosolic Ca 2+ concentration

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