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Topoisomerase I inhibitors: Camptothecins and beyond

1 H NMR (700 MHz, D 2 O) : 4.72 (s, 2H, H 11 ), 4.40 (d, J = 12.0 Hz, 1H, H 2 ), 4.35 (q, J = 11.0 Hz, 2H, H 13 ), 4.27 (d, J = 12.0 Hz, 1H, H 2 ), 3.66 (t, J = 7.0 Hz, 1H, H 4 ), 2.612.51 (m, 2H, H 5 )

Additionally, BH 4 may prevent CoQ 10 depletion by alleviating oxidative stress and by promoting its synthesis by converting phenylalanine into tyrosine, which can further be converted into a CoQ 10 precursor (4HB), thereby reducing lipid peroxidation levels via CoQ 10

[DOI] [PMC free article] [PubMed] [Google Scholar] Lima K.M., Vago J.P., Caux T.R., Negreiros-Lima G.L., Sugimoto M.A., Tavares L.P., Arribada R.G., Carmo A.A.F., Galvao I., Costa B.R.C., Soriani F.M., Pinho V., Solito E., Perretti M., Teixeira M.M., Sousa L.P

To make sure it is safe for you, before using the medicine let your doctor also know if you have any medical conditions such as Leber's disease, liver disease, or kidney disorder.