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106 PanBXuLWengJWangYJiHHanBet al

The molecular mechanism underlying the relationship between OXPHOS and PDAC progression still requires in-depth study with bright prospects (Text Box S2)

Serum levels of IGF-I and of IGFBP-3 did not increase

The citric acid cycle involves three NAD+-dependent dehydrogenase reactions: isocitrate dehydrogenase, -ketoglutarate dehydrogenase, and malate dehydrogenase, each generating NADH while releasing carbon dioxide and regenerating oxaloacetate for continued cycle operation