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Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion

Using a validated scoring algorithm, the Actiware software translates the activity data to sleep-wake patterns and activity level

b , Relative fold change in cell growth between shCtrl and shGDH1 groups

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The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events