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2018 July 31;18(1):772

Neurobiol Dis 16(2):440453

found that anti-PD-1, alone or in combination with anti-CTLA-4, failed to inhibit tumor growth in mice receiving a standard diet, whereas KD implementation, or oral administration of 3-hydroxybutyrate (3-HB), a principal KB generated in the KD, reestablished therapeutic responses

There was also a significant increase in urine of m+3 orotate, which is derived from pyruvate carboxylation to oxaloacetate, demonstrating another mechanism by which Cse / mice can waste carbon in the absence of CoA (Extended Data Fig

Particularly, FAS and ACSL5 expression is known to be upregulated transcriptionally, at least in part, because of the existence of SREBF1 binding sites on their genes promoter (70, 71)