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Hyperalgesia and Allodynia: Cases of hyperalgesia and allodynia have been reported with opioid therapy of any duration (see WARNINGS)

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Shen et al., 2023), by disrupting blood-brain barrier integrity and inducing neuroinflammation (Lananna and Musiek, 2020

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The optimal pH level for bathing is between 5.5 and 6.5, which closely matches the skin's natural pH

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Curcumin targets the Keap1-Nrf2 pathway by modifying Keap1s thiol groups, destabilizing the Keap1-Nrf2 complex, and blocking Nrf2 ubiquitination

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