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Physiol Rev 87, 245313

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Since all live cells need NAD + which declines with age, and all cells we know about develop oxyradical damage with age, our drug combination of an NAD precursor and a Nrf2 inducer is likely to benefit brain glia, vascular, and other age-susceptible systems including kidney, heart, and immune systems

Bharat S et al: Pre-teatment with R-lipoic acid alleviates the effects of GDH depletion in PC12 cells: implications for Parkinsons disease therapy

Double-blind, placebo-controlled study of L-acetylcarnitine for the treatment of hyperactive behavior in fragile X syndrome