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The author makes nine assumptions to justify increasing the final infusion of NAC, including that 25-50% of the APAP will become NAPQI and that no further absorption of acetaminophen will occur after the initial overdose

10.1038/nature11007 62 GallagherC

Anticancer activity of the choline kinase inhibitor PL48 is due to selective disruption of choline metabolism and transport systems in cancer cell lines