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In vivo rodent studies have used continuous subcutaneous infusion via osmotic minipump and once-daily subcutaneous injection

In mice, 125 I-labeled SOD1-containing nanoparticles display increased stability in blood and in the brain, and improved accumulation in brain tissues, in comparison with non-cross-linked complexes and native SOD1 (Klyachko et al., 2012)

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However, some patients experience nausea as a temporary side effect, which may be less disruptive if it occurs during morning hours when food intake is lighter

Then, m6A peaks were acquired by the ExomePeak software (version 3.8) based on the Ensembl database