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Conformational changes in PDI alter its compact conformation and expose the normally shielded hydrophobic regions, which regulates its chaperone activity (Wang et al., 2012, 2015)

doi: 10.3390/antiox12071398 98

This doesn't mean glutathione is ineffective it simply means the science is still evolving, and consumers should approach it with informed, realistic expectations

Toxicological sciences : an official journal of the Society of Toxicology , 147 (2), 466-474

The final analysis from its Phase III clinical trials showed a 94.1% efficacy in preventing COVID-19 illness and a 100% efficacy in preventing severe COVID-19