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Unlike flavokavain A, flavokavain B induced G2/M cell cycle arrest in cancer cells regardless of the p53 status [128,131,132,134,136,137], which is intriguing given their similar structures (Figure 2)

This gives rise to increased fluorescence

J Biol Chem 279: 2593525938 Acknowledgements We thank The Wellcome Trust and the Biotechnology and Biological Sciences Research Council for financial support

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In addition, Tirzepatide also binds to GIP receptors on -cells to co-stimulate insulin secretion by upregulating intracellular cAMP levels via GPCR-signaling