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doi: 10.1126/science.aan3706 104 MatsonVFesslerJBaoRChongsuwatTZhaYAlegreMLet al

Growth hormone is secreted in pulses rather than a steady stream, and the single largest pulse happens shortly after you fall asleep, during deep slow-wave sleep

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16,17,18,56 Meanwhile, the improved oxygen availability alleviates the hypoxic suppression of BMAL1, thereby enabling its transcriptional activity and promoting a pro-regenerative outcome in bone regeneration