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In brief, NRF2 detaches from Kelch-like ECH-associated protein 1 and translocates to the nucleus, where it activates the expression of downstream target genes containing antioxidant responsive elements

Conclusion Reactive oxygen species play a dual role in the liver serving as indispensable messengers in normal physiology while acting as pathological drivers when chronically elevated

To address this need, this study develops a digital simulation tool that integrates high-precision mobility data with extensive open spatial datasets, enabling planners to evaluate and predict the costs and impacts of public transportation strategies quickly and affordably

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