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Name: glutathione skin lightening evidence safety Systematic Review of the Efficacy and of Topical in Dermatology Glutathione as a skin‐lightening agent
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Int J Mol Sci 24(2):1150

As of July 2026, no PDUFA (target action) date has been publicly confirmed

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Mitochondrial Ca 2+ overload due to MCU overactivation increases Ca 2+ sensitivity, enhancing myosin light chain phosphorylation and promoting contraction, and mitochondrial ROS activate redox-sensitive pathways such as MAPK and NF-B, driving VSMC proliferation and neointima formation

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