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The MNs developed by the team are manufactured in a differential dual-release manner, with the outer layer replacing the aluminum adjuvant to form an antigen reservoir for sustained antigen release and the inner layer rapidly releasing the adjuvant to activate DCs, effectively reducing the amount of aluminum while maintaining its effect (Fig

Meanwhile, of Americans suffer with chronic pain and most are fatigued

It is currently understood that small molecules capable of traversing the OM either possess specific physicochemical properties that enable crossing of this barrier by passive diffusion or hijacking porins or other membrane-embedded proteins (Fig

Alberti, S

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