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Genetic alteration, inflammation, uncontrolled cell proliferation, and oxidative stress are important factors contributing to their progression (Tapia-Vieyra et al., 2017)

[34] Unlike bidirectional and specific origin initiation of nuclear DNA replication, mitochondrial DNA has two strand-specific, unidirectional origins of replication of the leading H strand (O H ) which located in NCR and the lagging L strand (O L ) which located in the tRNA gene cluster

www.R-project.org), resulting in the final output file titled unique_genes_matrix.tsv. This matrix contained quantified gene-specific peptides filtered using a global false discovery rate (FDR) of 1%, applying both global q-values for protein groups and global as well as run-specific q-values for precursors