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Each manufacturer could theoretically optimize a select number of cytokines, but not all of them (e.g., the most sensitive and specific antibody for a given cytokine would have to be replaced by another antibody that is less cross-reactive)

Elevated ROS levels have also been linked to neuronal hyperexcitability and impaired synaptic transmission in neuropathic pain models, such as the spared nerve injury (SNI) model, which exacerbates pain perception [50]