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Future research should concentrate on (1) elucidating nAChR roles in genetic PD subtypes (e.g., GBA or SNCA mutation carriers), (2) developing disease-modifying strategies targeting nAChR-ligand interactions beyond symptomatic relief, and (3) integrating multi-omics approaches to identify nAChR-associated biomarkers predictive of therapeutic response

Pontillo CA, Garca MA, Pea D, Cocca C, Chiappini F, Alvarez L, et al

Clinical studies indicated that strain HN019 significantly enhanced GI health and modulated immune responses (57)

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