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Tozadenant showed positive effect on reducing OFF-time duration in a phase IIb, double-blind randomized trial (Hauser et al

46 Interactions of Dopamine Receptors With Other Proteins The interactions of dopamine receptors with other proteins are, it is clear, a key step when it comes to determining their function

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SIRT1 regulates lipid homeostasis by suppressing lipogenic transcription factors such as sterol regulatory element-binding protein 1 (SREBP1), reducing triglyceride synthesis and preventing fat accumulation in the liver (Yin et al., 2014)