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It was originally identified as a fragment derived from a larger protein found in human gastric juice, which sparked early scientific interest due to its unusual stability and biological activity under experimental conditions

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Detailed analysis of subsynaptic processes of the ME5 showed the translation at presynapse, regulation of postsynaptic density assembly, SV exocytosis, chemical synaptic transmission, and neurotransmitter receptor localization of postsynaptic specialization membrane (Fig

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