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[Abstract]2023 Apr;1869(4):166656

Duration of estrogen exposure during reproductive years, age at menarche and age at menopause, and risk of cardiovascular disease events, all-cause and cardiovascular mortality: a systematic review and meta-analysis

Yes the version sold contains legal ephedra extract (herbal), not ephedrine alkaloids banned by the FDA

Nov 1 2018;22(4):369-374

People with diabetes or impaired glucose tolerance are more likely to have RLS, and RLS is a prominent part of diabetic peripheral neuropathy (Bosco 2009