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The initial dosing starts at 0.25 mg per week and is gradually increased at 4-week intervals to 0.5, 1.0, 1.7 mg, and finally to a maximum dose of 2.4 mg per week

When a ligand binds to the extracellular receptor, this initiates a signal transduction cascade that induces a conformational change, promoting the activation of the heterotrimeric GTP-binding protein (G-protein) (79)

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Synthetic d 9 -BB was prepared as a chloride salt from -aminobutyric acid in methanol with potassium hydrogen carbonate and d 3 -methyl iodide, as previously described (26)

UPC, Urine protein-to-creatinine ratio