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Cacao was first brought to Europe by the Spanish through commerce with the Aztec tribes, where it was blended with milk, sugar, or honey to make the oldest form of what would later become chocolate

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Methods Patient selection The inclusion criteria for the patients were as follows: patients 1) with histologically or cytologically proven non-Sq NSCLC and MPM, 2) planning to use pemetrexed-containing chemotherapy, 3) nave or previously treated with chemotherapy, 4) with ECOG-PS of 02, 5) age 20 years, 6) with adequate organ function measured as leukocyte count 3,000 /L, hemoglobin concentration 10.0 g/dL, platelet count 100,000 /L, total bilirubin level 2.0 mg/dL, transaminase levels 100 IU/L, serum creatinine level 1.5 mg/dL, SpO 2 (percutaneous oxygen saturation) 90% in ambient air, 7) expected to survive at least 12 weeks from the start of treatment, and 8) who provided written informed consent

The use of EGb 761 significantly reduces the above-mentioned cytotoxic mediators, which were found in the brains of animals supplemented with EGb 761

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