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It serves as the rate-limiting enzyme for the de novo synthesis of GSH, which is promoted by glutamate cysteine ligase (GCL) and glutathione synthetase (GSS)

In combination, both products overlap in benefits and synergetically help each other function

Overall diet history and reversibility of the metabolic syndrome over 5 years: The Whitehall II prospective cohort study

Without the addition of glutathione, the pathway, briefly reconstituted by the addition of methylcobalamin alone will sputter, like an unused engine, creating inefficient function, and an imbalance of related methylation reactions producing an abundance of pathway inhibiting substances like SAH

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