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Microglial membranes have a range expression of receptors, including neurotransmitter receptors (e.g., glutamatergic, GABAergic, norepinephrine, acetylcholine, cannabinoid) [58], pattern recognition receptors (e.g., Toll-like receptors, NOD-like receptors, and C-type lectin receptors), immunomodulatory receptors, scavenger receptors, cytokine and chemokine receptors [59]

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On the opposite knowing that the cause for cognitive decline is not AD can help identify other causes of brain dysfunction such as vascular dementia, autoimmune conditions, toxic exposure

doi: 10.1111/j.1538-7836.2009.03568.x 21 HuijbersMGZhangWKloosterRNiksEHFrieseMBStraasheijmKRet al