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10.1016/j.tem.2008.11.001 Trends Endocrinol

Although therapeutic options are available for chronic pain and depression, less than 50% of all patients treated for chronic pain report a clinically meaningful (i.e., 50%) pain relief with current analgesic treatments, and only about 5060% of patients with major depressive disorders achieved remission after an adequate course with conventional antidepressants

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However, in other semen parameters, there was no significant difference between two groups (29)