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Similarly, apolipoprotein A-IV, which is synthesized and secreted exclusively by the small intestine (primarily by the jejunum, but also by the duodenum and ileum), acts as a satiety factor that is downregulated by leptin (188) and upregulated by insulin and PYY in both rodents and humans (189)

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Neither compound should be considered a licensed medicine in the UK, and both require careful scrutiny before any consideration of use

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Diabetes 50 : 11101118 Yakar S et al