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A randomized, controlled trial of the pan-PPAR agonist lanifibranor in NASH

10.1016/j.bioactmat.2022.11.006 51 LiuH.TianX.JinC.LiY.ZhuX.PeiM.et al (2024a)

6, 2021, article 1915

Treatment of AMs with synthetic miR-21-5p mimics or miR-NC revealed that miR-21-5p significantly reduced the intracellular bacterial counts of Actinobacillus pleuropneumoniae (APP) when compared to miR-NC treatment( Figure 4D ) through a novel mechanism: the PIK3CD gene in AMs is targeted to activate the PI3K/Akt pathway, which in turn induces autophagy, this inhibits the overproduction of ROS and activates the NLRP3 inflammasome, preventing focal death and improving bacterial clearance