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found that the valine-citrulline (Val-Cit) linker exhibits broad sensitivity to a variety of cathepsins, including cathepsin B, cathepsin K, cathepsin L, and more

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It delays the onset of ALS, increases the survival of spinal motor neurons, preserves the function of the lower and upper motor neuron (Mancuso et al., 2014a, b), attenuates the loss of motor neurons and improves muscle atrophy and mitochondrial function of muscle fibers in a SOD1 G93A mouse model of ALS (Song et al., 2014) (Table 1)

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