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Similar content being viewed by others Introduction Cardiovascular disease (CVD) is a severe health problem and one of the leading causes of death globally 1

Dysfunction of MCUC increases calcium ion concentration in the endoplasmic reticulum, promoting vasoconstriction and mitochondrial fission while simultaneously reducing calcium concentration within the mitochondria and inhibiting calcium-dependent metabolic enzymes, thereby suppressing oxidative metabolism [102]

Amino acid metabolism Amino acid metabolism, which can affect cancer cell status and systemic metabolism through energy metabolism and signal transduction, is deregulated in PDAC [47]