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We sought to test the hypothesis that inhibition of the CD38 ecto-enzymatic activity using a heavy-chain monoclonal antibody Ab68 will, via augmenting organismal NAD + , prevent fibrosis in a mouse model of SSc characterized by NAD + depletion

Strategies for maintaining weight loss after tirzepatide include gradual tapering rather than abrupt cessation, establishing strong dietary and exercise habits during treatment, and potentially continuing on a reduced maintenance dose