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As shown in Figure S7, key differences in the binding modes of non-cyclic ligand 7a and cyclic ligands 7b 7i were revealed through analysis of their intermolecular interaction profiles, with 7a forming numerous but low-frequency contacts - likely due to its flexible warhead - while the more rigid cyclic ligands engaged in fewer but higher-frequency interactions, indicating slightly greater binding specificity and complex stability

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Wearden AJ, Morriss RK, Mullis R, et al

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Tumor Volume Monitoring Solid tumor volume was monitored by using Vernier caliper