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The MHRA (2022) recently issued guidance on the increased risk of vitamin B12 deficiency in people treated with metformin, highlighting increased risks with higher metformin doses, longer treatment duration and in patients with risk factors for B12 deficiency, including the following: Existing low B12 levels

[96] found there was no statistical difference in mitochondrial respiration in natural killer (NK) cells of ME/CFS patients compared with age and sex-matched non-fatigued healthy controls

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Specifically they all made substantial contributions to the conception or design of the work, the acquisition, analysis or interpretation of data, and drafting of the article or reviewing it critically for important intellectual content

[DOI] [PMC free article] [PubMed] [Google Scholar] 223.Wisner KL, Stika CS, Watson K