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Microenvironmental cues promoting the DTP phenotype Several studies have shown that the acidic, hypoxic and nutrient-depleted tumour niche favours the emergence of DTPs (reviewed elsewhere 146 )

Non-Specific Binding Non-specific binding occurs when proteins other than the target interact with the GST tag or the glutathione beads

Moreover, mitochondrial morphology of SLC27A5-overexpressing HCC cells manifested as decreased even vanished mitochondria cristae, and increased mitochondrial membrane density compared to the control group (Fig