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While ROS are reduced to water, their oxidised forms are quite stable and unreactive, thus posing minimal cellular damage (Flora, 2009)

Strength: 25mg

Metabolism Selinexor is metabolized by CYP3A4, multiple UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs)

When is suitable for the reaction of exogenous chemicals in large doses, may make the depletion of glutathione, a metabolic saturation (metabolic saturation), and in combined with the amount of time no longer increases with the increase of the exogenous chemicals dosage

While acute liver injury can occur when used at or below the recommended daily maximum dose (4000 mg)[4], paracetamol toxicity is often the result of ingestion of paracetamol over this maximum dose