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Long-Term (after several weeks of continuous use): The effects tend to stabilize

None of the GSTU sequences identified in poplar possesses a recognizable targeting sequence, suggesting that all these proteins are likely cytosolic as already suggested for other GSTU proteins ( GSTU genes, Potri.008G174900 and Potri.008G175000, which, respectively, code for PtGSTU19 and PtGSTU20, are two adjacent and paralogous genes that share 91% sequence identity (Supplementary Figures S1, S2)

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In the context of hepatic IR associated with non-alcoholic fatty liver disease (NAFLD), this molecular pathway becomes dysregulated, leading to impaired suppression of hepatic gluconeogenesis