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A recent review has documented this synergy (McGuire et al., Curr Rev Musculoskelet Med 2025)

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Furthermore, a 2-year, double-blind, randomized, placebo-controlled therapeutic trial in 158 healthy siblings of hyperhomocysteinemic patients with premature atherothrombotic disease folic acid plus vitamin B 6 treatment was associated with a decreased occurrence of abnormal exercise electrocardiography tests, which is consistent with a decreased risk of atherosclerotic events (Vermeulen et al, 2000)

The supernatants were further clarified through a 0.45-m filter and applied onto GSTrap FF columns (GE Healthcare Life Sciences), which had been equilibrated with buffer B