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The critical role of glucuronidase treatment has also been emphasized by Ali et al

Reports of initial SAM-e supplementation trials reported as much as 50% degradation during storage (8)

Those with extensive stage disease may receive other regimens such as irinotecan (Camptosar, CPT-11) with cisplatin (NCCN 2014b

doi: 10.1016/j.bbapap.2014.01.002

Therefore, limiting Asn metabolism in tumor cells and immunosuppressive cells in the TME and protecting and promoting Asn metabolism in anti-tumor immune cells should be a problem to be solved