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Further, the loss of Hb by use of a novel T-lymphocyte-specific Hb knock-out mouse impairs mitochondrial function, dysregulates cytokine production, and lowers the activation threshold primarily in CD4 + T-lymphocytes, indicating a critical role for Hb within this subset

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Li, Z.-T., Yu, S.-B., Liu, Y., Tian, J

Notably, we provided the first evidence regarding the epigenetic-mediated regulatory mechanisms underlying GPX7 activation in gliomas

However, minor genetic effects are not excluded by this study