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With some exceptions, a small portion of proteins can interact with the 20S and be degraded through a ubiquitin-independent pathway [21]

10.3389/fpsyt.2023.1071769 Front

Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation