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Although the liver is a major metabolic organ, the effect of AKI on the hepatic metabolome has not previously been examined to our knowledge

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For example, Lactobacillus plantarum 69-2 coupled with galactooligosaccharides (GOS) could regulate the intestinal flora of D-gal-induced mice, prevent the decrease in Shannon index, affect the flora structure, increase the level of SCFA and the thickness of intestinal mucosa, protect the intestinal barrier, and then activate the adenosine 5-monophosphate-activated protein kinase/Sirtuin-1 (AMPK/SIRT1) pathway, reduce the level of aging-related genes (Wang et al., 2021)

Sustained effect of prasinezumab on Parkinsons disease motor progression in the open-label extension of the PASADENA trial