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It is perhaps for this reason that the less stable apoSOD1 is more rapidly degraded under physiological conditions by both the 20S proteasome and macroautophagy than its holoSOD1 contemporary

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doi: 10.1016/j.phymed.2012.07.001

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Total RNA was isolated using the RNAqueous Total RNA Isolation Kit AM1912 (Life Technologies Corp., Grand Island, New York, USA)

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