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doi: 10.1101/gad.271130.115 17 CheungE

For example, the role of macrophages in inflammation has moved away from the dichotomy of pro-inflammatory M1 and anti-inflammatory M2 cells, being replaced by a more nuanced view, encompassing a diversity of heterogeneous macrophage sub-types, likely with specialized functions [36]

Figure 6 7 Autophagy as a survival strategy in infected macrophages Autophagy is a highly conserved process through which eukaryotic cells sequester their own cytoplasmic contents into a phagophore and later recycle them via lysosomes for the metabolic processes of the cell (Gomes and Dikic, 2014)

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Tsvetkov Shannon P, Boryana C, Margaret P, Ana D, Mai V, Jordan A, Lena R, Ranad J, Ryan DH, John KS, Evgeni E, Mustafa F, Steven MK, Svetlana C, Naama L, Sandro K, Todd RS, Todd RG