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Supplemental Figure Acknowledgments We express our thanks to professor Huiliang Li (Wolfson Institute for Biomedical Research, UCL) for his helpful discussion of the project, critical reading and kind suggestions to the manuscript

Ethics statement The studies involving humans were approved by Amsterdam UMC location, Vrije Universiteit Amsterdam, Department of Hematology/Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands

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In individuals with knee osteoarthritis, the level of hyaluronic acid decreases, leading to increased friction, pain, and stiffness