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Compared to UBE2m RK, fatty acid metabolism and mitochondrial respiration were inhibited after re-expression of UBE2m WT, and the suppressed OCR was rescued significantly after treatment with MLN4924 (Figs

There are some animal studies that show it might be possible, but scientists aren't sure yet

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In addition, AS-IV inhibited intestinal FXR signaling, reduced intestinal FGF15 expression, thereby reducing liver FXR activation, increased glucagon-like peptide-1 secretion, and ultimately suppressed SREBP-1c-mediated lipogenesis and liver steatosis (Zhai et al., 2022)