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These include environmental factors, such as ultraviolet (UV) radiation and environmental pollutants, including ozone and cigarette smoke (115, 116)

By age 50-60, many men experience clinically significant testosterone deficiency, presenting as: Persistent fatigue and reduced motivation Loss of muscle mass and strength Increased body fat, particularly visceral (abdominal) fat Decreased libido and sexual function Mood changes including irritability and mild depression Reduced bone mineral density Growth Hormone Decline Growth hormone secretion declines approximately 14% per decade after age 30, a process termed somatopause (2)

Mateja et al

Therapeutic effects of aerosolized amantadine in naturally acquired infection due to influenza A virus