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474,475 eNAMPT regulates glucose production via the PKA/CREB signaling in HepG2 cells

10.4161/auto.26094 216

227 Further in-depth analysis and validation of these hits, including identification of their targets, assessment of their impact on disease-related signaling pathways, and testing for consistency and reproducibility across various model systems, are essential to determine their genuine therapeutic potential and developmental value

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These findings are bolstered by clinical observations in treatment-seeking populations, where heavy drinkers frequently present with symptoms overlapping MDD criteria, including anhedonia, psychomotor retardation, and pervasive guilt, often persisting into early abstinence and complicating recovery trajectories (Cheng et al