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Its potential against acute and latent M.tb infections is still under investigation, and small-scale clinical trials may be necessary to assess its anti-TB efficacy either as a monotherapy or in combination with other anti-TB drugs

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The disease may have two formsan acute one characterized by hemorrhagic diarrhea and sudden death, and a chronic one with no hemorrhagic diarrhea that causes wasting and loss of control (74)

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This clearly implies that, although several in vitro tests for genotoxicity assessment are available at different stages of development and acceptance, they cannot be considered to fully replace animal tests needed to evaluate the safety of substances (see Adler et al., 2011)