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Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase

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Scientific interest in these compounds focuses on understanding their biological activity, molecular signalling, cellular responses, and interactions with physiological pathways involved in tissue biology

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Milestones in LPA discovery and research LPA was initially regarded as a minor phospholipid intermediate, but over the past five decades, it has emerged as a central signaling molecule with broad physiological and pathological relevance